Entry Detail


General Information

Database ID:exR0409505
RNA Name:hsa-miR-206
RNA Type:miRNA
Chromosome:chr6
Starnd:+
Coordinate:
Start Site(bp):52144401End Site(bp):52144422
External Links:hsa-miR-206



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CAPNS1
chr19
36139953
36150353
+
NPEPPS
chr17
47522942
47623276
+
SPRED1
chr15
38252836
38357249
+
SLC30A7
chr1
100896076
100981757
+
DDX5
chr17
64498254
64508199
-
TRIM2
chr4
153152342
153339317
+
DLG3
chrX
70444835
70505490
+
LASP1
chr17
38869859
38921770
+
RTL8B
chrX
135020513
135022542
-
FOXP1
chr3
70952817
71583993
-
SDCBP
chr8
58552924
58582859
+
NME1-NME2
chr17
51153590
51171744
+
NR2C2
chr3
14947584
15053600
+
TNRC6B
chr22
40044817
40335808
+
CREB3L2
chr7
137874979
138002086
-
NETO2
chr16
47077703
47143945
-
ZNF518A
chr10
96129715
96205288
+
PGM2
chr4
37826660
37862937
+
PRR12
chr19
49591182
49626439
+
PTBP1
chr19
797075
812327
+
CALM1
chr14
90396502
90408268
+
NME2
chr17
51165435
51171747
+
AP1S1
chr7
101154456
101161596
+
MAPK1
chr22
21754500
21867680
-
GID4
chr17
18039408
18068405
+
SMCO4
chr11
93478472
93543391
-
SS18
chr18
26016253
26091217
-
CWC15
chr11
94962620
94973586
-
WIPF2
chr17
40219304
40284136
+
WDR5
chr9
134135365
134159968
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000816
chr17
80521229
80526077
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005332.7
chr17
68188547
68189165
+
AC145207.5
chr17
81878425
81881106
-
LINC00641
chr14
21200079
21206900
-
MALAT1
chr11
65497688
65506516
+
MIR4435-2HG
chr2
111006015
111523376
-
NEAT1
chr11
65422774
65445540
+
RMRP
chr9
35657751
35658018
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.