Entry Detail


General Information

Database ID:exR0409531
RNA Name:hsa-miR-23b-3p
RNA Type:miRNA
Chromosome:chr9
Starnd:+
Coordinate:
Start Site(bp):95085265End Site(bp):95085287
External Links:hsa-miR-23b-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ATAD1
chr10
87751512
87841343
-
ATXN7L3
chr17
44191805
44200113
-
BRWD1
chr21
39184176
39321559
-
CNOT6L
chr4
77713387
77819615
-
GATAD2B
chr1
153789030
153923360
-
HMGCS1
chr5
43287470
43313512
-
KLF12
chr13
73686089
73995056
-
KLF3
chr4
38664197
38701517
+
PHLDA1
chr12
76025447
76033932
-
TK2
chr16
66508003
66552544
-
TNFAIP3
chr6
137867214
137883312
+
TOB2
chr22
41433494
41446801
-
VDAC1
chr5
133971871
134004975
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0000711
chr16
68155889
68160513
+
hsa_circ_0000881
chr19
5653125
5654467
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007780.1
chr17
68413623
68524949
+
AC011503.2
chr19
23927788
23929287
+
AC078846.1
chr7
129604548
129611630
-
AC091564.7
chr11
6610883
6616594
-
AC124068.2
chr15
89335053
89336161
+
AC144548.1
chr12
110387463
110445548
-
AL035458.2
chr20
34234840
34281173
-
GAS5
chr1
173858559
173868882
-
MALAT1
chr11
65497688
65506516
+
MCM3AP-AS1
chr21
46229196
46259390
+
NEAT1
chr11
65422774
65445540
+
SNHG16
chr17
76557764
76565348
+
SNHG5
chr6
85650491
85678932
-
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
TYMSOS
chr18
630886
658340
-
XIST
chrX
73820649
73852723
-
Z93241.1
chr22
42615244
42615907
+
ZNF674-AS1
chrX
46545438
46548841
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.