Entry Detail


General Information

Database ID:exR0409535
RNA Name:hsa-miR-25-3p
RNA Type:miRNA
Chromosome:chr7
Starnd:-
Coordinate:
Start Site(bp):100093571End Site(bp):100093592
External Links:hsa-miR-25-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ADCY9
chr16
3953387
4116442
-
ARMC1
chr8
65602458
65634217
-
BCL9
chr1
147541501
147626216
+
CCDC186
chr10
114120862
114174232
-
CERK
chr22
46684410
46738252
-
EIF1AX
chrX
20124525
20141838
-
EML4
chr2
42169353
42332548
+
FNBP4
chr11
47716494
47767443
-
ITGAV
chr2
186590056
186680901
+
MRS2
chr6
24402908
24426194
+
MTHFD2
chr2
74198610
74217565
+
MYH9
chr22
36281277
36388067
-
NFIB
chr9
14081843
14398983
-
NSMAF
chr8
58583508
58659853
-
PALLD
chr4
168497052
168928457
+
PPAT
chr4
56393362
56435615
-
PUS7
chr7
105439661
105522271
-
RBFOX2
chr22
35738736
36028824
-
RNF38
chr9
36336396
36487548
-
RNF4
chr4
2462220
2625320
+
RRN3
chr16
15060022
15094317
-
SH3PXD2A
chr10
103594027
103855543
-
SOX4
chr6
21593751
21598619
+
TXLNA
chr1
32179675
32198285
+
UBE2N
chr12
93405673
93441947
-
USP21
chr1
161159450
161165723
+
XRN1
chr3
142306607
142448062
-
TXNRD3
chr3
126607059
126655124
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0001414
chr4
56277780
56284152
+
hsa_circ_0000126
chr1
150997086
150999803
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005394.2
chr19
28435388
28727680
-
AC074117.1
chr2
27356246
27367622
+
AC130650.2
chr16
14150833
14153235
+
DAPK1-IT1
chr9
87553454
87554459
+
LINC01128
chr1
825138
859446
+
MALAT1
chr11
65497688
65506516
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
PITPNA-AS1
chr17
1516931
1518096
+
PURPL
chr5
27217714
27496994
+
SNHG5
chr6
85650491
85678932
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.