Entry Detail


General Information

Database ID:exR0409547
RNA Name:hsa-miR-28-5p
RNA Type:miRNA
Chromosome:chr3
Starnd:+
Coordinate:
Start Site(bp):188688794End Site(bp):188688815
External Links:hsa-miR-28-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RTL8A
chrX
135050932
135052196
-
LYPD3
chr19
43460787
43465608
-
RGMA
chr15
93035273
93089204
-
GLYR1
chr16
4803203
4847288
-
E2F6
chr2
11444375
11466177
-
PTPN23
chr3
47381011
47413435
+
KCTD5
chr16
2682523
2709030
+
GPCPD1
chr20
5544439
5611006
-
ENSA
chr1
150600851
150629612
-
AMOTL2
chr3
134355874
134375479
-
SSR2
chr1
156009048
156020951
-
FAM102A
chr9
127940582
127980989
-
N4BP1
chr16
48538726
48620148
-
CPSF2
chr14
92121969
92172145
+
EZH1
chr17
42700275
42745049
-
KIAA1522
chr1
32741830
32774970
+
LONRF2
chr2
100271875
100322501
-
MAPK1
chr22
21754500
21867680
-
LASP1
chr17
38869859
38921770
+
SMYD1
chr2
88067825
88113384
+
NAPA
chr19
47487637
47515091
-
URGCP
chr7
43875894
43926411
-
SMG5
chr1
156249224
156282825
-
DYRK1A
chr21
37365573
37526358
+
RTL8B
chrX
135020513
135022542
-
SLC31A1
chr9
113221544
113264492
+
SEH1L
chr18
12947133
12987536
+
ZBTB7B
chr1
155002630
155018522
+
TUB
chr11
8019244
8106112
+
TEX261
chr2
70985942
70994873
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000417
chr12
69644908
69656342
+
hsa_circ_0001146
chr20
34241449
34246936
-
hsa_circ_0001164
chr20
45891031
45923523
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC009065.4
chr16
2119207
2120248
+
AC016876.2
chr17
7581964
7584086
-
AC026362.1
chr12
122975320
122982907
+
AC118758.3
chr7
56809214
56848800
-
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
OIP5-AS1
chr15
41283990
41309737
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.