Entry Detail


General Information

Database ID:exR0409567
RNA Name:hsa-miR-31-5p
RNA Type:miRNA
Chromosome:chr9
Starnd:-
Coordinate:
Start Site(bp):21512158End Site(bp):21512178
External Links:hsa-miR-31-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABHD4
chr14
22598237
22613215
+
ANKRD52
chr12
56237807
56258384
-
BACH2
chr6
89926528
90296908
-
CHD1
chr5
98853985
98928957
-
CTNND1
chr11
57753243
57819546
+
FAM222B
chr17
28755978
28855232
-
FURIN
chr15
90868588
90883458
+
GRK2
chr11
67266473
67286556
+
HACD3
chr15
65530418
65578349
+
HOXA7
chr7
27153716
27157936
-
KIF3B
chr20
32277651
32335011
+
LONRF1
chr8
12721906
12756073
-
MAP3K14
chr17
45263119
45317029
-
PATL1
chr11
59636716
59669037
-
PLCB1
chr20
8077251
8968360
+
PPP1R3C
chr10
91628442
91633071
-
PRRC2B
chr9
131373636
131500197
+
RTL8B
chrX
135020513
135022542
-
RTL8C
chrX
135032355
135033546
+
SERF2
chr15
43777087
43802589
+
SMAD3
chr15
67063763
67195169
+
TRIM35
chr8
27284886
27311272
-
XPNPEP3
chr22
40857077
40932815
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001728
chr7
99695763
99695845
-
hsa_circ_0001349
chr3
152132729
152150709
+
hsa_circ_0000241
chr10
70847874
70856944
+
hsa_circ_0000931
chr19
38226804
38231095
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004832.5
chr22
30420512
30420912
+
AC016876.2
chr17
7581964
7584086
-
AC074117.1
chr2
27356246
27367622
+
AC087477.2
chr15
96354237
96405235
+
GAS5
chr1
173858559
173868882
-
MAGI2-AS3
chr7
79452877
79471208
+
MIR497HG
chr17
7015818
7019659
-
NEAT1
chr11
65422774
65445540
+
SNHG16
chr17
76557764
76565348
+
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.