Entry Detail


General Information

Database ID:exR0409585
RNA Name:hsa-miR-320a-3p
RNA Type:miRNA
Chromosome:chr8
Starnd:-
Coordinate:
Start Site(bp):22244975End Site(bp):22244996
External Links:hsa-miR-320a-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACAP2
chr3
195274745
195443044
-
ASB1
chr2
238426742
238452250
+
BLCAP
chr20
37492472
37527931
-
BTAF1
chr10
91923770
92030325
+
CGN
chr1
151510510
151538692
+
CKAP5
chr11
46743048
46846308
-
CRTC3
chr15
90529923
90645345
+
FJX1
chr11
35618460
35620865
+
GMCL1
chr2
69829660
69881384
+
GNAI2
chr3
50226292
50259362
+
HECTD2
chr10
91409280
91514829
+
HSP90AB1
chr6
44246166
44253888
+
IGF2BP3
chr7
23310209
23470491
-
MKI67
chr10
128096659
128126423
-
NR4A2
chr2
156324437
156342348
-
PFN1
chr17
4945652
4949061
-
SGK1
chr6
134169246
134318112
-
SIN3A
chr15
75369379
75455842
-
SRSF7
chr2
38743599
38751494
-
TRIM14
chr9
98069275
98119222
-
VMA21
chrX
151396515
151409364
+
ZCCHC2
chr18
62523025
62587709
+
CDK2AP1
chr12
123250112
123272334
-
CTNNA1
chr5
138610967
138935034
+
HLA-DRA
chr6
32439878
32445046
+
MIF
chr22
23894383
23895227
+
PCLAF
chr15
64364304
64387687
-
SLC5A3
chr21
34073578
34106260
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC002044.1
chr16
73014319
73014476
-
AC016876.2
chr17
7581964
7584086
-
AC092718.4
chr16
81030770
81031485
+
AL022311.1
chr22
37876148
37895563
+
AL162258.1
chr1
153626332
153634340
-
DLEU1
chr13
50082169
50906856
+
GAS5
chr1
173858559
173868882
-
LINC00641
chr14
21200079
21206900
-
MALAT1
chr11
65497688
65506516
+
MIR3142HG
chr5
160438594
160487426
+
NEAT1
chr11
65422774
65445540
+
NR2F2-AS1
chr15
96110040
96327361
-
OIP5-AS1
chr15
41283990
41309737
+
SNHG1
chr11
62851984
62855953
-
SNHG12
chr1
28578538
28583132
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.