Entry Detail


General Information

Database ID:exR0409599
RNA Name:hsa-miR-330-5p
RNA Type:miRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):45639049End Site(bp):45639070
External Links:hsa-miR-330-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ZNF3
chr7
100064033
100082548
-
ALDH5A1
chr6
24494867
24537207
+
ENG
chr9
127815012
127854756
-
NEMP1
chr12
57055643
57088063
-
STX3
chr11
59713456
59805882
+
RTL10
chr22
19846138
19854896
-
GIPC1
chr19
14477760
14496149
-
ANKRD13B
chr17
29589769
29614761
+
UBE4A
chr11
118359585
118399211
+
MARK2
chr11
63838928
63911019
+
ATXN1
chr6
16299112
16761491
-
NME4
chr16
396725
410367
+
TMEM127
chr2
96248516
96265994
-
PDXK
chr21
43719094
43762307
+
GUCD1
chr22
24540423
24555935
-
MTG2
chr20
62183029
62203568
+
VLDLR
chr9
2621787
2660056
+
EIF4A1
chr17
7572706
7579006
+
GIGYF1
chr7
100679507
100694037
-
DOLPP1
chr9
129081111
129090438
+
SMAD3
chr15
67063763
67195169
+
MAP4
chr3
47850690
48089272
-
ABL1
chr9
130713016
130887675
+
PAQR4
chr16
2969270
2973484
+
NR4A2
chr2
156324437
156342348
-
CRTC3
chr15
90529923
90645345
+
PPME1
chr11
74171267
74254703
+
GOSR2
chr17
46923075
46975524
+
MYO1C
chr17
1464186
1492686
-
AGTRAP
chr1
11736084
11754802
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000128
chr1
151139409
151139890
+
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0001727
chr7
99621041
99621930
+
hsa_circ_0001865
chr9
86292641
86293514
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC016876.2
chr17
7581964
7584086
-
AC144548.1
chr12
110387463
110445548
-
AL355075.4
chr14
20343048
20343685
-
AL359924.1
chr1
237862175
237928321
+
AP000553.1
chr22
21652270
21670237
+
KCNQ1OT1
chr11
2608328
2699994
-
MIRLET7BHG
chr22
46053869
46113928
+
NEAT1
chr11
65422774
65445540
+
SNHG1
chr11
62851984
62855953
-
SNHG3
chr1
28505980
28510892
+
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.