Entry Detail


General Information

Database ID:exR0409614
RNA Name:hsa-miR-345-5p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):100307876End Site(bp):100307897
External Links:hsa-miR-345-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC011455.2
chr19
38915404
38949855
-
CNBP
chr3
129169484
129183922
-
FAM222B
chr17
28755978
28855232
-
GCNT4
chr5
75025346
75052558
-
GPD2
chr2
156435290
156613735
+
HEG1
chr3
124965710
125055997
-
IGF2BP1
chr17
48997385
49056145
+
LCLAT1
chr2
30447226
30644225
+
MAP3K14
chr17
45263119
45317029
-
MAPK1
chr22
21754500
21867680
-
RCOR1
chr14
102592649
102730561
+
RIPOR1
chr16
67518418
67546788
+
SARS2
chr19
38915266
38930896
-
SPTBN2
chr11
66685248
66729226
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001867
chr9
86294689
86297981
-
hsa_circ_0001866
chr9
86293355
86297981
-
hsa_circ_0001392
chr4
3088665
3109150
+
hsa_circ_0001387
chr4
1902352
1936989
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC079781.5
chr7
97851688
97972985
-
GAS5
chr1
173858559
173868882
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC01772
chr1
16460948
16468481
+
NEAT1
chr11
65422774
65445540
+
SNHG15
chr7
44983023
44986961
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.