Entry Detail


General Information

Database ID:exR0409622
RNA Name:hsa-miR-362-3p
RNA Type:miRNA
Chromosome:chrX
Starnd:+
Coordinate:
Start Site(bp):50009005End Site(bp):50009026
External Links:hsa-miR-362-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
PTPRJ
chr11
47980558
48170841
+
KIAA0232
chr4
6781375
6884170
+
USF2
chr19
35268962
35279821
+
BLCAP
chr20
37492472
37527931
-
AC009133.6
chr16
29812261
29820092
+
WDR82
chr3
52254434
52288020
-
PIP4K2B
chr17
38765689
38800126
-
ARF3
chr12
48935723
48957487
-
TRPS1
chr8
115408496
115809673
-
UBTF
chr17
44205033
44221626
-
FAM126B
chr2
200973718
201071671
-
ZBTB2
chr6
151364115
151391559
-
TNFRSF21
chr6
47231532
47309905
-
RUNX1
chr21
34787801
36004667
-
MTPN
chr7
135926760
135977359
-
SERTAD3
chr19
40440844
40444335
-
DCBLD2
chr3
98795941
98901695
-
ATP8B1
chr18
57646426
57803315
-
SLF2
chr10
100912963
100965134
+
SDCBP
chr8
58552924
58582859
+
TNFRSF1B
chr1
12166991
12209228
+
COQ8A
chr1
226897536
226987545
+
DNAJB9
chr7
108569867
108574850
+
VAMP2
chr17
8159149
8163546
-
SIK1B
chr21
6111131
6123778
+
SMAP2
chr1
40344850
40423326
+
FAM219A
chr9
34398184
34458570
-
CA12
chr15
63321378
63381846
-
CALM1
chr14
90396502
90408268
+
AKAP11
chr13
42272152
42323261
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001588
chr6
26204839
26205043
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC016876.2
chr17
7581964
7584086
-
KCNQ1OT1
chr11
2608328
2699994
-
MIR663AHG
chr20
26167817
26251546
-
NEAT1
chr11
65422774
65445540
+
SCARNA9
chr11
93721513
93721865
+
SNHG25
chr17
64145970
64146476
+
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.