Entry Detail


General Information

Database ID:exR0409673
RNA Name:hsa-miR-432-5p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):100884496End Site(bp):100884518
External Links:hsa-miR-432-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ABL1
chr9
130713016
130887675
+
ANXA2
chr15
60347134
60402883
-
ATP5MC3
chr2
175176258
175184607
-
BLCAP
chr20
37492472
37527931
-
CA12
chr15
63321378
63381846
-
CALM1
chr14
90396502
90408268
+
CELSR2
chr1
109249539
109275751
+
CHTF8
chr16
69118010
69132578
-
DNAJC13
chr3
132417502
132539032
+
EPB41
chr1
28887091
29120046
+
FADS2
chr11
61792980
61867354
+
FN1
chr2
215360440
215436073
-
GGA3
chr17
75236599
75262363
-
GNAI2
chr3
50226292
50259362
+
HMBOX1
chr8
28890395
29064764
+
IGF1R
chr15
98648539
98964530
+
IPO9
chr1
201829149
201884291
+
KDM3B
chr5
138352685
138437028
+
MFHAS1
chr8
8783354
8893630
-
NAPEPLD
chr7
103099776
103149560
-
PHC3
chr3
170086732
170181749
-
PRELID3B
chr20
59033145
59042809
-
PTCD3
chr2
86106223
86142157
+
RASA1
chr5
87267883
87391931
+
SETD7
chr4
139495941
139606699
-
STAMBP
chr2
73828916
73873659
+
TMEM63A
chr1
225845536
225882380
-
TOB2
chr22
41433494
41446801
-
ZBTB34
chr9
126860665
126885878
+
ZNF12
chr7
6688433
6706947
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001454
chr4
154524454
154533552
+
hsa_circ_0001349
chr3
152132729
152150709
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC009133.5
chr16
29808679
29812227
+
AC016876.2
chr17
7581964
7584086
-
AC068768.1
chr12
123262060
123262402
+
AC239868.1
chr1
149861271
149862504
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC00649
chr21
33915534
33977691
+
NEAT1
chr11
65422774
65445540
+
PCBP2-OT1
chr12
53464468
53465057
+
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
ZFAS1
chr20
49278178
49299600
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.