Entry Detail


General Information

Database ID:exR0409687
RNA Name:hsa-miR-4485-3p
RNA Type:miRNA
Chromosome:chr11
Starnd:-
Coordinate:
Start Site(bp):10508277End Site(bp):10508296
External Links:hsa-miR-4485-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
C11orf24
chr11
68261338
68272001
-
CDK4
chr12
57747727
57756013
-
CKAP5
chr11
46743048
46846308
-
CYB561A3
chr11
61348745
61362299
-
SERINC1
chr6
122443351
122471807
-
NES
chr1
156668763
156677407
-
NDUFB11
chrX
47142216
47145504
-
FUBP1
chr1
77944055
77979110
-
RPL27
chr17
42998273
43002959
+
YEATS2
chr3
183697797
183812624
+
CIRBP
chr19
1259384
1274880
+
DNM1
chr9
128191655
128255248
+
MAP3K11
chr11
65597756
65615382
-
RPL13
chr16
89560657
89566828
+
EXOSC6
chr16
70246778
70251940
-
SBF2
chr11
9778667
10294207
-
HSPA8
chr11
123057489
123063230
-
RPS27A
chr2
55231903
55235853
+
EIF3F
chr11
7970251
8001862
+
RNASEH2C
chr11
65714005
65720818
-
FAU
chr11
65120630
65122177
-
HSP90AB1
chr6
44246166
44253888
+
RPS3
chr11
75399515
75422280
+
NR3C1
chr5
143277931
143435512
-
SPG11
chr15
44562696
44663678
-
MTRNR2L6
chr7
142666272
142667718
+
LGR4
chr11
27365961
27472790
-
FRMD8
chr11
65386621
65413525
+
CRTC3
chr15
90529923
90645345
+
MTRNR2L12
chr3
96617188
96618236
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
MALAT1
chr11
65497688
65506516
+
XIST
chrX
73820649
73852723
-
AD000090.1
chr19
35557956
35581954
+
LINC01002
chr19
198264
246544
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.