Entry Detail


General Information

Database ID:exR0409690
RNA Name:hsa-miR-4492
RNA Type:miRNA
Chromosome:chr11
Starnd:+
Coordinate:
Start Site(bp):118910765End Site(bp):118910781
External Links:hsa-miR-4492



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AGFG1
chr2
227472152
227561214
+
NRARP
chr9
137299631
137302271
-
RHOA
chr3
49359145
49412998
-
AATF
chr17
36948954
37056871
+
ANOS1
chrX
8528874
8732137
-
DDRGK1
chr20
3190350
3204685
-
FBXL3
chr13
76992598
77027195
-
LEPR
chr1
65420652
65641559
+
MDP1
chr14
24213943
24216070
-
MELTF
chr3
196988621
197029817
-
NCKAP5L
chr12
49791146
49828750
-
PKN3
chr9
128702503
128720916
+
RNF149
chr2
101271219
101308701
-
SH3BP2
chr4
2793071
2841098
+
SNAPC2
chr19
7920338
7923250
+
SOCS2
chr12
93569814
93583487
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AL096870.2
chr14
24209646
24215987
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.