Entry Detail


General Information

Database ID:exR0409692
RNA Name:hsa-miR-449a
RNA Type:miRNA
Chromosome:chr5
Starnd:-
Coordinate:
Start Site(bp):55170586End Site(bp):55170607
External Links:hsa-miR-449a



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AKAP13
chr15
85380571
85749358
+
UBXN2B
chr8
58411359
58451501
+
ACSL1
chr4
184755595
184826818
-
CALM3
chr19
46601074
46610782
+
SUPT6H
chr17
28662198
28702679
+
STK38L
chr12
27243968
27325959
+
NPTX1
chr17
80466834
80477843
-
PPARD
chr6
35342558
35428191
+
MID1
chrX
10445310
10833654
-
PER2
chr2
238244044
238290102
-
C2CD5
chr12
22448583
22544546
-
GNA12
chr7
2728105
2844308
-
DEDD2
chr19
42198598
42220140
-
PHF19
chr9
120855651
120894896
-
CCDC86
chr11
60842113
60851081
+
PRR12
chr19
49591182
49626439
+
ATXN2L
chr16
28823035
28837237
+
MLLT1
chr19
6210381
6279975
-
ANGEL1
chr14
76786168
76826246
-
CD151
chr11
832887
839831
+
NTN4
chr12
95657807
95791152
-
DLL1
chr6
170282206
170306565
-
ZNF512B
chr20
63956704
63969930
-
NCOA1
chr2
24491914
24770702
+
ZNF623
chr8
143636013
143656418
+
HOXB8
chr17
48611377
48615292
-
JPH1
chr8
74234700
74321540
-
CRTC3
chr15
90529923
90645345
+
TMEM109
chr11
60914158
60923443
+
ZDHHC17
chr12
76763588
76853696
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001723
chr7
91924202
91948826
+
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0000038
chr1
28800065
28802803
+
hsa_circ_0001865
chr9
86292641
86293514
-
hsa_circ_0001146
chr20
34241449
34246936
-
hsa_circ_0001164
chr20
45891031
45923523
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC018521.1
chr17
47945424
47981736
+
AC116913.1
chr15
66488658
66492109
-
HCG18
chr6
30286690
30327382
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC00665
chr19
36313067
36331770
-
NEAT1
chr11
65422774
65445540
+
SNHG7
chr9
136721366
136728184
-
TERC
chr3
169764520
169765060
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.