Entry Detail


General Information

Database ID:exR0409704
RNA Name:hsa-miR-454-3p
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):59137787End Site(bp):59137809
External Links:hsa-miR-454-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TARDBP
chr1
11012344
11026420
+
PPP1R9A
chr7
94907202
95296415
+
KIAA0232
chr4
6781375
6884170
+
ITGB8
chr7
20330702
20415754
+
PHF20
chr20
35771974
35950370
+
ATP6V1C1
chr8
103021063
103073051
+
CALU
chr7
128739292
128773400
+
CIT
chr12
119685791
119877320
-
G6PD
chrX
154531391
154547572
-
CHD9
chr16
53055033
53329150
+
BHLHE40
chr3
4979437
4985323
+
ADARB1
chr21
45073853
45226560
+
SLC12A7
chr5
1050384
1112063
-
EIF5A2
chr3
170888418
170908644
-
TGIF2
chr20
36573488
36593950
+
AKAP10
chr17
19904302
19978343
-
MLPH
chr2
237485428
237555322
+
CD151
chr11
832887
839831
+
LDLRAD3
chr11
35943981
36232136
+
UBQLN1
chr9
83659968
83707958
-
APCDD1
chr18
10454635
10489949
+
SYNJ1
chr21
32628759
32728048
-
MPPED2
chr11
30384493
30586872
-
LYSMD2
chr15
51723011
51751585
-
PRICKLE2
chr3
64092236
64445476
-
MLLT1
chr19
6210381
6279975
-
RTN4
chr2
54972187
55112621
-
MTMR9
chr8
11284816
11328146
+
MAP3K20
chr2
173075435
173268015
+
SH3PXD2A
chr10
103594027
103855543
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000591
chr15
41961025
41962156
+
hsa_circ_0001454
chr4
154524454
154533552
+
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0001723
chr7
91924202
91948826
+
hsa_circ_0000892
chr19
11941431
12014514
+
hsa_circ_0001605
chr6
42903447
42905047
+
hsa_circ_0000155
chr1
168007608
168014465
+
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0000018
chr1
15860731
15863309
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC011503.2
chr19
23927788
23929287
+
AC021092.1
chr19
44103007
44113183
-
AC135050.6
chr16
31122235
31124064
+
AC234582.1
chr1
155195004
155205495
+
AL031595.3
chr22
44139365
44153626
+
AL049840.4
chr14
103694516
103695050
-
AL158206.1
chr9
19453209
19455173
+
AL158825.2
chr9
75009828
75016036
-
AL603839.3
chr1
40493157
40508661
-
CKMT2-AS1
chr5
81201341
81301565
-
H19
chr11
1995176
2001470
-
HAGLR
chr2
176164051
176188958
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC01089
chr12
121795267
121803906
-
MIR17HG
chr13
91347820
91354579
+
NEAT1
chr11
65422774
65445540
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.