Entry Detail


General Information

Database ID:exR0409737
RNA Name:hsa-miR-485-5p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):101055427End Site(bp):101055448
External Links:hsa-miR-485-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ZDHHC18
chr1
26826688
26857604
+
ZNF106
chr15
42412823
42491141
-
IFI6
chr1
27666064
27672198
-
FAM102A
chr9
127940582
127980989
-
SUMF2
chr7
56064002
56080670
+
TAOK1
chr17
29390464
29551904
+
MAP7D1
chr1
36155579
36180849
+
PSKH1
chr16
67893254
67929676
+
TSPAN4
chr11
842812
867116
+
GOLGA3
chr12
132768914
132829078
-
RAB35
chr12
120095099
120117502
-
MPDU1
chr17
7583529
7592789
+
THY1
chr11
119417378
119424985
-
TSR2
chrX
54440404
54448032
+
AP1M1
chr19
16197578
16245907
+
ARRDC1
chr9
137605685
137615360
+
COQ9
chr16
57447425
57461270
+
RMI2
chr16
11249619
11381662
+
MEPCE
chr7
100428790
100434118
+
GBF1
chr10
102245532
102382899
+
KRT80
chr12
52168996
52192014
-
CAPZB
chr1
19338775
19485539
-
GRHL2
chr8
101492439
101669726
+
RHOB
chr2
20447074
20449440
+
INO80
chr15
40978880
41116280
-
ABAT
chr16
8674596
8784575
+
B4GALT5
chr20
49632945
49713878
-
RCC2
chr1
17406760
17439677
-
AKT2
chr19
40230317
40285536
-
SMAD7
chr18
48919853
48952052
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001454
chr4
154524454
154533552
+
hsa_circ_0000417
chr12
69644908
69656342
+
hsa_circ_0000798
chr17
65941524
65944422
+
hsa_circ_0000552
chr14
71880664
71948928
+
hsa_circ_0001146
chr20
34241449
34246936
-
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005899.4
chr17
32328441
32329395
+
AC016065.1
chr8
6403551
6407142
-
AC016355.1
chr15
67541072
67542604
-
AC016876.2
chr17
7581964
7584086
-
AC026362.1
chr12
122975320
122982907
+
AC069281.2
chr7
100572232
100578700
-
AC074117.1
chr2
27356246
27367622
+
AC118758.3
chr7
56809214
56848800
-
AL022311.1
chr22
37876148
37895563
+
AL132655.2
chr20
58817132
58817725
-
AP000662.1
chr11
57638024
57652790
+
COL4A2-AS2
chr13
110456396
110463287
-
GAS5
chr1
173858559
173868882
-
LINC00265
chr7
39733430
39793092
+
LINC01278
chrX
63222993
63561095
-
LINC01772
chr1
16460948
16468481
+
MALAT1
chr11
65497688
65506516
+
MIR29B2CHG
chr1
207801518
207879115
-
NEAT1
chr11
65422774
65445540
+
NUTM2A-AS1
chr10
87201647
87342612
-
SNHG16
chr17
76557764
76565348
+
SNHG3
chr1
28505980
28510892
+
XIST
chrX
73820649
73852723
-
ZFHX2-AS1
chr14
23511760
23560778
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.