Entry Detail


General Information

Database ID:exR0409741
RNA Name:hsa-miR-493-3p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):100869116End Site(bp):100869137
External Links:hsa-miR-493-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ANKS1A
chr6
34889255
35091406
+
ASF1B
chr19
14119512
14136613
-
BACH2
chr6
89926528
90296908
-
BRPF3
chr6
36196744
36232790
+
C17orf49
chr17
7014495
7017525
+
DYNLRB1
chr20
34516409
34540958
+
EPG5
chr18
45847609
45967329
-
HIF1AN
chr10
100529072
100559998
+
MEX3A
chr1
156072013
156082465
-
MFN2
chr1
11980181
12013514
+
MMGT1
chrX
135962070
135974063
-
MTUS1
chr8
17643795
17800917
-
NPTX1
chr17
80466834
80477843
-
PRKAR2A
chr3
48744597
48847874
-
PXN
chr12
120210439
120265771
-
RNASEK-C17orf49
chr17
7012635
7017520
+
XPO6
chr16
28097979
28211920
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001146
chr20
34241449
34246936
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC016831.1
chr7
130876809
130913310
-
AC016876.2
chr17
7581964
7584086
-
AC022167.2
chr16
8848105
8860456
+
AC144548.1
chr12
110387463
110445548
-
AL359924.1
chr1
237862175
237928321
+
MIR200CHG
chr12
6963246
6964447
+
TUG1
chr22
30969245
30979395
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.