Entry Detail


General Information

Database ID:exR0409759
RNA Name:hsa-miR-5100
RNA Type:miRNA
Chromosome:chr10
Starnd:+
Coordinate:
Start Site(bp):42997630End Site(bp):42997651
External Links:hsa-miR-5100



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
SNU13
chr22
41673933
41690504
-
GHITM
chr10
84139509
84153568
+
AGRN
chr1
1020120
1056118
+
PRRC2B
chr9
131373636
131500197
+
HNRNPH1
chr5
179614178
179634784
-
GTF3C4
chr9
132670035
132694953
+
PPCDC
chr15
75023586
75117462
+
SLC35B1
chr17
49700934
49709014
-
SRP72
chr4
56467617
56503681
+
SRPK1
chr6
35832966
35921342
-
CHPF
chr2
219538948
219543809
-
NOP14
chr4
2937933
2963406
-
SLC52A2
chr8
144354135
144361272
+
THOP1
chr19
2785503
2815807
+
MACF1
chr1
39081316
39487177
+
CPTP
chr1
1324756
1328896
+
UBR4
chr1
19074510
19210266
-
ZNF136
chr19
12163064
12189871
+
HCN1
chr5
45254948
45696498
-
NUP93
chr16
56730118
56850286
+
KCTD2
chr17
75032575
75065889
+
NIN
chr14
50719763
50831121
-
KDSR
chr18
63327726
63367228
-
ATP1A1
chr1
116372668
116410261
+
PRMT6
chr1
107056674
107067636
+
FLNA
chrX
154348524
154374638
-
NUP107
chr12
68686951
68745809
+
P4HTM
chr3
48989889
49007153
+
VSIG10
chr12
118063593
118136026
-
WASF2
chr1
27404230
27490167
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
POLR2J4
chr7
43940895
44019175
-
SNHG3
chr1
28505980
28510892
+
AC008738.2
chr19
33305036
33309387
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.