Entry Detail


General Information

Database ID:exR0409791
RNA Name:hsa-miR-574-5p
RNA Type:miRNA
Chromosome:chr4
Starnd:+
Coordinate:
Start Site(bp):38868056End Site(bp):38868078
External Links:hsa-miR-574-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CCDC88C
chr14
91271323
91417844
-
CARMIL1
chr6
25279078
25620530
+
AHCYL1
chr1
109984765
110023742
+
ARID3A
chr19
925781
975939
+
CHD7
chr8
60678740
60868028
+
IDH3A
chr15
78131498
78171945
+
FAM102A
chr9
127940582
127980989
-
EEF2K
chr16
22206278
22288738
+
LRP8
chr1
53242364
53328469
-
SMCO4
chr11
93478472
93543391
-
ALDOA
chr16
30064164
30070457
+
ZNF621
chr3
40524878
40574685
+
MAP7D1
chr1
36155579
36180849
+
RAB10
chr2
26034084
26137454
+
TACC1
chr8
38728186
38853028
+
KLF11
chr2
10042849
10054836
+
TEAD1
chr11
12674421
12944737
+
MGRN1
chr16
4616493
4690974
+
SLC9A1
chr1
27098809
27166981
-
FNDC3A
chr13
48975912
49209779
+
SLC25A43
chrX
119399336
119454478
+
CTSD
chr11
1752755
1764573
-
PHF20L1
chr8
132775358
132848807
+
DCAF8
chr1
160215715
160262549
-
PIK3R3
chr1
46040140
46133036
-
RHOU
chr1
228735479
228746664
+
GALNT3
chr2
165747588
165794659
-
HOXC8
chr12
54008985
54012769
+
NID1
chr1
235975830
236065109
-
WSB2
chr12
118032694
118062430
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005394.2
chr19
28435388
28727680
-
AC021092.1
chr19
44103007
44113183
-
AL358472.3
chr1
153966516
153966930
+
DSCAM-AS1
chr21
40383083
40385358
+
NEAT1
chr11
65422774
65445540
+
SNHG7
chr9
136721366
136728184
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.