Entry Detail


General Information

Database ID:exR0409808
RNA Name:hsa-miR-625-5p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):65471116End Site(bp):65471136
External Links:hsa-miR-625-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
PPP2R1A
chr19
52190048
52229518
+
SF3B3
chr16
70523791
70577670
+
LRFN1
chr19
39306568
39315336
-
SLC6A6
chr3
14402576
14489349
+
VPS37B
chr12
122865330
122896127
-
SMARCC2
chr12
56162359
56189567
-
WIZ
chr19
15419978
15449956
-
SLC7A5
chr16
87830023
87869507
-
MED22
chr9
133338312
133348131
-
PPARD
chr6
35342558
35428191
+
FAM102A
chr9
127940582
127980989
-
ABL2
chr1
179099330
179229684
-
PPP6C
chr9
125146573
125189939
-
ABCF2
chr7
151207837
151227166
-
ABHD14A-ACY1
chr3
51974706
51989183
+
BCL9L
chr11
118893875
118925608
-
JUN
chr1
58780791
58784047
-
NUMB
chr14
73275107
73458617
-
SDF2
chr17
28648346
28662189
-
SREBF2
chr22
41833079
41907307
+
COL6A2
chr21
46098112
46132848
+
ACY1
chr3
51983340
51989197
+
E2F1
chr20
33675477
33686385
-
PRDX2
chr19
12796820
12801800
-
MSI1
chr12
120341330
120369164
-
COPS7B
chr2
231781671
231809254
+
CPSF7
chr11
61402641
61430031
-
SCAMP4
chr19
1905372
1926013
+
ITGA5
chr12
54395261
54419266
-
RNF44
chr5
176526712
176538025
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001434
chr4
106345352
106377902
-
hsa_circ_0001409
chr4
48835417
48859382
+
hsa_circ_0001358
chr3
169694733
169706147
+
hsa_circ_0001146
chr20
34241449
34246936
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC010542.4
chr16
66549280
66551189
+
AC145207.5
chr17
81878425
81881106
-
AC234582.1
chr1
155195004
155205495
+
H19
chr11
1995176
2001470
-
LINC00240
chr6
26956932
27059749
+
MALAT1
chr11
65497688
65506516
+
SNHG7
chr9
136721366
136728184
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.