Entry Detail


General Information

Database ID:exR0409812
RNA Name:hsa-miR-641
RNA Type:miRNA
Chromosome:chr19
Starnd:-
Coordinate:
Start Site(bp):40282603End Site(bp):40282626
External Links:hsa-miR-641



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AIF1L
chr9
131096476
131123152
+
AKT2
chr19
40230317
40285536
-
C19orf47
chr19
40319536
40348527
-
CDKN1A
chr6
36676460
36687339
+
F11R
chr1
160995211
161021343
-
FOXN3
chr14
89124871
89619149
-
GATAD2B
chr1
153789030
153923360
-
GCNT2
chr6
10492223
10629368
+
GNPTAB
chr12
101745499
101830959
-
HMGA2
chr12
65824131
65966295
+
ICE1
chr5
5420664
5490220
+
JPT1
chr17
75135248
75168281
-
LSM14A
chr19
34172504
34229515
+
MED13L
chr12
115953872
116277719
-
PRSS16
chr6
27247701
27256624
+
SETD7
chr4
139495941
139606699
-
SOCS3
chr17
78356778
78360077
-
SYNJ2BP
chr14
70366499
70417090
-
SYNJ2BP-COX16
chr14
70326064
70417074
-
ZDHHC6
chr10
112424428
112446917
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001085
chr2
191765289
191789319
+
hsa_circ_0001168
chr20
47691321
47707559
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC125257.1
chr17
41848518
41851447
-
AC239868.1
chr1
149861271
149862504
+
AL034397.3
chrX
66015461
66020422
+
AL049795.2
chr1
32170733
32176568
+
AL355075.4
chr14
20343048
20343685
-
DLEU2
chr13
49956670
50125720
-
LINC00641
chr14
21200079
21206900
-
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
SNHG1
chr11
62851984
62855953
-
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.