Entry Detail


General Information

Database ID:exR0409824
RNA Name:hsa-miR-654-5p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):101040234End Site(bp):101040255
External Links:hsa-miR-654-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
BCL9L
chr11
118893875
118925608
-
ATP11A
chr13
112690329
112887168
+
PHB
chr17
49404049
49414905
-
ZDHHC3
chr3
44915257
44976185
-
PKM
chr15
72199029
72231822
-
ATXN7L3
chr17
44191805
44200113
-
SH3PXD2A
chr10
103594027
103855543
-
ITGA5
chr12
54395261
54419266
-
TP53
chr17
7661779
7687550
-
CBFA2T3
chr16
88874858
88977207
-
CS
chr12
56271699
56300391
-
LY6E
chr8
143017982
143023832
+
SPINT1
chr15
40844018
40858207
+
AGTRAP
chr1
11736084
11754802
+
URM1
chr9
128371361
128392016
+
BCL7A
chr12
122019422
122062044
+
MEF2D
chr1
156463727
156500779
-
DHCR24
chr1
54849627
54887195
-
JADE2
chr5
134524312
134583230
+
LSM12
chr17
44034328
44067619
-
ZMIZ1
chr10
79068966
79316528
+
TOB2
chr22
41433494
41446801
-
ACTN4
chr19
38647649
38731589
+
XPO6
chr16
28097979
28211920
-
KMT2D
chr12
49018975
49059774
-
SMAD3
chr15
67063763
67195169
+
BCAM
chr19
44809071
44821421
+
IGF2BP1
chr17
48997385
49056145
+
GID4
chr17
18039408
18068405
+
NID1
chr1
235975830
236065109
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000417
chr12
69644908
69656342
+
hsa_circ_0000642
chr15
80390757
80415142
+
hsa_circ_0000816
chr17
80521229
80526077
+
hsa_circ_0000643
chr15
80412669
80415142
+
hsa_circ_0000943
chr19
47421744
47440665
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC239868.1
chr1
149861271
149862504
+
AL035458.2
chr20
34234840
34281173
-
AL356488.2
chr1
109100193
109100619
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.