Entry Detail


General Information

Database ID:exR0409831
RNA Name:hsa-miR-665
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):100875075End Site(bp):100875094
External Links:hsa-miR-665



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
GINS1
chr20
25407673
25452628
+
TMED10
chr14
75131469
75176612
-
C19orf12
chr19
29698886
29715789
-
STX6
chr1
180972712
181023121
-
CTSD
chr11
1752755
1764573
-
CCNF
chr16
2429394
2458854
+
GREB1
chr2
11482341
11642788
+
IRF4
chr6
391752
411443
+
COX8A
chr11
63974620
63976543
+
ABHD2
chr15
89087459
89202355
+
CLDN11
chr3
170418865
170454733
+
ZNF527
chr19
37371061
37393066
+
ZBTB7A
chr19
4043303
4066899
-
TAF5L
chr1
229593111
229626047
-
CIPC
chr14
77098126
77117287
+
C6orf120
chr6
169702190
169704856
+
HADHA
chr2
26190635
26244672
-
EXOSC6
chr16
70246778
70251940
-
TSPAN4
chr11
842812
867116
+
EHD2
chr19
47713422
47743134
+
KLHDC3
chr6
43014103
43021298
+
CACUL1
chr10
118674167
118755249
-
RBM33
chr7
155644451
155781485
+
GUCD1
chr22
24540423
24555935
-
ELN
chr7
74027789
74069907
+
RHOF
chr12
121777754
121803403
-
VMA21
chrX
151396515
151409364
+
CBFB
chr16
67028984
67101058
+
STX3
chr11
59713456
59805882
+
TNFRSF1B
chr1
12166991
12209228
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000417
chr12
69644908
69656342
+
hsa_circ_0000402
chr12
53670403
53671011
+
hsa_circ_0000798
chr17
65941524
65944422
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0001387
chr4
1902352
1936989
+
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005394.2
chr19
28435388
28727680
-
AC018521.1
chr17
47945424
47981736
+
AC023509.1
chr12
53441741
53467528
+
AC118758.3
chr7
56809214
56848800
-
AC234582.1
chr1
155195004
155205495
+
AL355987.4
chr9
136799223
136810042
+
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
LINC00665
chr19
36313067
36331770
-
LINC00910
chr17
43338741
43389199
-
LINC01089
chr12
121795267
121803906
-
LINC01535
chr19
37251885
37265535
+
MIR29B2CHG
chr1
207801518
207879115
-
MIR497HG
chr17
7015818
7019659
-
NEAT1
chr11
65422774
65445540
+
OIP5-AS1
chr15
41283990
41309737
+
SND1-IT1
chr7
127997597
128000077
+
SNHG16
chr17
76557764
76565348
+
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.