Entry Detail


General Information

Database ID:exR0409852
RNA Name:hsa-miR-6838-5p
RNA Type:miRNA
Chromosome:chr7
Starnd:-
Coordinate:
Start Site(bp):44073407End Site(bp):44073428
External Links:hsa-miR-6838-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:NA
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0001723
chr7
91924202
91948826
+
hsa_circ_0000458
chr12
124071293
124074996
+
hsa_circ_0001699
chr7
40027197
40041630
+
hsa_circ_0001387
chr4
1902352
1936989
+
hsa_circ_0001168
chr20
47691321
47707559
+
hsa_circ_0000552
chr14
71880664
71948928
+
hsa_circ_0000038
chr1
28800065
28802803
+
hsa_circ_0000652
chr15
90984737
90986710
+
hsa_circ_0001472
chr5
36953719
36976504
+
hsa_circ_0001263
chr3
5215701
5216099
+
hsa_circ_0000799
chr17
65941524
65972074
+
hsa_circ_0001164
chr20
45891031
45923523
-
hsa_circ_0000032
chr1
25666964
25669564
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC003092.1
chr7
94022833
94066661
+
NUTM2B-AS1
chr10
79661394
79826594
-
LINC02035
chr3
122886941
122892416
+
AL031282.2
chr1
1702736
1737688
-
AC009022.1
chr16
69976297
70065948
-
AC020978.7
chr16
68224713
68227734
+
MIR29B2CHG
chr1
207801518
207879115
-
AC002470.2
chr22
20979462
20998121
+
LINC01184
chr5
127939152
128083172
-
SNHG12
chr1
28578538
28583132
-
XIST
chrX
73820649
73852723
-
AC021078.1
chr5
149494314
149504670
-
AC021092.1
chr19
44103007
44113183
-
AL359924.1
chr1
237862175
237928321
+
MIR497HG
chr17
7015818
7019659
-
HCG18
chr6
30286690
30327382
-
LINC00649
chr21
33915534
33977691
+
SNHG25
chr17
64145970
64146476
+
AC079781.5
chr7
97851688
97972985
-
AP000317.2
chr21
34073592
34360033
+
AC114980.1
chr5
93860669
93863825
-
NEAT1
chr11
65422774
65445540
+
SNHG16
chr17
76557764
76565348
+
LINC00662
chr19
27681072
27794005
-
MIR503HG
chrX
134543119
134546642
-
STAG3L5P-PVRIG2P-PILRB
chr7
100336104
100367831
+
AL391244.1
chr1
1420245
1422691
+
SNHG1
chr11
62851984
62855953
-
MCM3AP-AS1
chr21
46229196
46259390
+
MZF1-AS1
chr19
58559129
58574797
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.