Entry Detail


General Information

Database ID:exR0409864
RNA Name:hsa-miR-744-5p
RNA Type:miRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):12081909End Site(bp):12081930
External Links:hsa-miR-744-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AP5S1
chr20
3820524
3828838
+
ARHGDIA
chr17
81867721
81871378
-
ARL8A
chr1
202133404
202144743
-
C8orf82
chr8
144525733
144529132
-
CLSTN1
chr1
9728926
9823984
-
CMIP
chr16
81445170
81711762
+
DLGAP4
chr20
36306336
36528637
+
DNAJC30
chr7
73680918
73683453
-
EEF1A2
chr20
63488014
63499185
-
FAM219A
chr9
34398184
34458570
-
FAM83H
chr8
143723933
143738234
-
MGRN1
chr16
4616493
4690974
+
MIDN
chr19
1248553
1259140
+
NFIX
chr19
12995608
13098796
+
NRARP
chr9
137299631
137302271
-
PHB2
chr12
6965327
6970753
-
PRKCD
chr3
53156009
53192717
+
PRR12
chr19
49591182
49626439
+
RAI14
chr5
34656328
34832612
+
SCN1B
chr19
35030470
35040449
+
SH3GL1
chr19
4360370
4400547
-
SMAD3
chr15
67063763
67195169
+
SPRED2
chr2
65310851
65432637
-
SYVN1
chr11
65121780
65134533
-
WNT5A
chr3
55465715
55490539
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC002116.1
chr19
36008638
36014235
-
AC008738.7
chr19
33207129
33207639
+
AL356488.2
chr1
109100193
109100619
+
GAS5
chr1
173858559
173868882
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.