Entry Detail


General Information

Database ID:exR0409892
RNA Name:hsa-miR-9-3p
RNA Type:miRNA
Chromosome:chr15
Starnd:+
Coordinate:
Start Site(bp):89368071End Site(bp):89368092
External Links:hsa-miR-9-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:NA
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001025
chr2
69565029
69565697
-
hsa_circ_0001747
chr7
131071878
131084192
+
hsa_circ_0001409
chr4
48835417
48859382
+
hsa_circ_0000169
chr1
198190128
198233365
+
hsa_circ_0001746
chr7
131060182
131084192
+
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0000527
chr14
24610097
24616430
-
hsa_circ_0000744
chr17
15968183
15971435
-
hsa_circ_0001358
chr3
169694733
169706147
+
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004224.2
chr16
3458071
3515564
+
AL137129.1
chr14
61734138
61776260
+
LINC02035
chr3
122886941
122892416
+
MALAT1
chr11
65497688
65506516
+
MIR22HG
chr17
1711493
1717174
-
NORAD
chr20
36045618
36051018
-
SNHG1
chr11
62851984
62855953
-
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.