Entry Detail


General Information

Database ID:exR0409894
RNA Name:hsa-miR-92a-3p
RNA Type:miRNA
Chromosome:chrX
Starnd:-
Coordinate:
Start Site(bp):134169544End Site(bp):134169565
External Links:hsa-miR-92a-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
MAZ
chr16
29806106
29811164
+
RPS8
chr1
44775251
44778779
+
ESRP1
chr8
94641074
94707466
+
PTPRZ1
chr7
121873089
122062036
+
YIPF3
chr6
43511832
43516985
-
SEC63
chr6
107867756
107958208
-
NPM1
chr5
171387116
171411137
+
USP21
chr1
161159450
161165723
+
ZNF330
chr4
141220887
141234697
+
HBE1
chr11
5268345
5505652
-
EHMT2
chr6
31879759
31897687
-
PITPNA
chr17
1517718
1562792
-
RBBP5
chr1
205086142
205122015
-
PNKD
chr2
218270392
218346793
+
SMC1A
chrX
53374149
53422728
-
RWDD1
chr6
116571409
116597675
+
GLCE
chr15
69160584
69272217
+
CEP89
chr19
32875925
32971991
-
PPP3CB
chr10
73436428
73496024
-
HMGB1
chr13
30456704
30617597
-
KLF4
chr9
107484852
107490482
-
MRPS16
chr10
73248843
73252693
-
TCP1
chr6
159778498
159789703
-
EZR
chr6
158765741
158819368
-
PSMB8
chr6
32840717
32844679
-
RPL17-C18orf32
chr18
49481681
49492479
-
OGFOD1
chr16
56451521
56479104
+
MCM3
chr6
52264014
52284881
-
EIF4G2
chr11
10797050
10808940
-
RPL13A
chr19
49487554
49492308
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0001414
chr4
56277780
56284152
+
hsa_circ_0000126
chr1
150997086
150999803
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005394.2
chr19
28435388
28727680
-
AC074117.1
chr2
27356246
27367622
+
AC130650.2
chr16
14150833
14153235
+
DAPK1-IT1
chr9
87553454
87554459
+
LINC01128
chr1
825138
859446
+
MALAT1
chr11
65497688
65506516
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
PITPNA-AS1
chr17
1516931
1518096
+
PURPL
chr5
27217714
27496994
+
SNHG5
chr6
85650491
85678932
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.