exRNAdisease

Entry Detail

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General Information

Database ID: exR0428559 RNA Name: AACS RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 125065434 End Site(bp): 125143333 External Links: ENSG00000081760

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NPM3 chr10 101781325 101783413 - FGFR2 chr10 121478334 121598458 - PDXK chr21 43719094 43762307 + EXOC6B chr2 72175984 72826041 - SIPA1L2 chr1 232397965 232561558 - NOP14 chr4 2937933 2963406 - ZNF579 chr19 55576774 55580848 - MTERF4 chr2 241072169 241102332 - EIF6 chr20 35278911 35284985 - CITED2 chr6 139371807 139374648 - EME1 chr17 50373220 50381483 + PHLDA1 chr12 76025447 76033932 - RPLP2 chr11 809965 812880 + ZBTB44 chr11 130226677 130314917 - KLHL21 chr1 6590724 6614607 - TMEM259 chr19 1009648 1021179 - RPS5 chr19 58386400 58394806 + PCBP2 chr12 53452102 53481162 + VCP chr9 35056064 35072627 - BRD9 chr5 850291 892801 - TRIM13 chr13 49995888 50020481 + SUPT20H chr13 37009312 37059713 - AIFM2 chr10 70098223 70132934 - AL121753.1 chr20 35267885 35280043 - OST4 chr2 27070472 27071654 - HSP90AB1 chr6 44246166 44253888 + BCKDK chr16 31106107 31112791 + AAMP chr2 218264123 218270257 - SELENOH chr11 57741250 57743554 + BUD31 chr7 99408641 99419616 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.