exRNAdisease

Entry Detail

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General Information

Database ID: exR0428569 RNA Name: AARS2 RNA Type: mRNA Chromosome: chr6 Starnd: - Coordinate: Start Site(bp): 44298731 End Site(bp): 44313347 External Links: ENSG00000124608

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand COX5A chr15 74919791 74938083 - HSP90AB1 chr6 44246166 44253888 + DENND5A chr11 9138825 9265350 - SFT2D3 chr2 127701497 127705242 + USP22 chr17 20999596 21043760 - SRSF5 chr14 69726900 69772005 + FAM83D chr20 38926312 38953106 + RRP12 chr10 97356358 97426076 - WDR27 chr6 169457212 169702067 - KPNB1 chr17 47649476 47685505 + RAD23A chr19 12945855 12953642 + RBM8A chr1 145917714 145927678 - TIMELESS chr12 56416363 56449426 - MIDN chr19 1248553 1259140 + MT-ND2 chrMT 4470 5511 + GRAMD1A chr19 34994784 35026471 + TM9SF3 chr10 96518110 96587452 - TP53I11 chr11 44885903 44951306 - HSP90B1 chr12 103930107 103953645 + NDFIP1 chr5 142108779 142154440 + USP35 chr11 78188812 78215232 + RPL13 chr16 89560657 89566828 + EIF3C chr16 28688558 28735730 + DPPA4 chr3 109326141 109337572 - ARSA chr22 50622754 50628173 - TBL1XR1 chr3 177019340 177228000 - WDR74 chr11 62832342 62841809 - ORAI3 chr16 30949068 30956461 + PTOV1 chr19 49850735 49860744 + PML chr15 73994673 74047827 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC102953.2 chr7 1464497 1467522 - AL355075.4 chr14 20343048 20343685 - EBLN3P chr9 37079645 37090928 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.