exRNAdisease

Entry Detail

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General Information

Database ID: exR0428574 RNA Name: AATF RNA Type: mRNA Chromosome: chr17 Starnd: + Coordinate: Start Site(bp): 36948954 End Site(bp): 37056871 External Links: ENSG00000275700

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SSR1 chr6 7268306 7347446 - RPS19 chr19 41860255 41872925 + THY1 chr11 119417378 119424985 - EIF3B chr7 2354086 2380745 + CD74 chr5 150400041 150412929 - CASP2 chr7 143288215 143307696 + BDH1 chr3 197509783 197573323 - RNF113A chrX 119870475 119871733 - RTCA chr1 100266207 100292769 + AP002990.1 chr11 62559603 62591531 - CKB chr14 103519667 103522833 - CLDN23 chr8 8701937 8704096 + RPL8 chr8 144789765 144792587 - VLDLR chr9 2621787 2660056 + ACTB chr7 5527148 5563784 - MT-CO3 chrMT 9207 9990 + RPS6 chr9 19375715 19380236 - NIPA2 chr15 22838641 22868384 + UBA52 chr19 18571730 18577550 + DYNC1H1 chr14 101964573 102056443 + UBALD2 chr17 76265348 76271298 + LSM1 chr8 38163335 38176730 - CIC chr19 42268537 42295797 + PAQR3 chr4 78887127 78939438 - CCNA2 chr4 121816444 121823933 - TMEM258 chr11 61768501 61792802 - ACTR1B chr2 97655939 97664044 - CIT chr12 119685791 119877320 - FAN1 chr15 30890559 30943108 + SRGN chr10 69088103 69104805 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-4492 chr11 118910765 118910781 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL355987.4 chr9 136799223 136810042 + NAALADL2-AS2 chr3 175234861 175271096 - SNHG1 chr11 62851984 62855953 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.