exRNAdisease

Entry Detail

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General Information

Database ID: exR0428581 RNA Name: ABCA2 RNA Type: mRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 137007234 End Site(bp): 137028922 External Links: ENSG00000107331

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand STK11 chr19 1177558 1228431 + SLC36A4 chr11 93144174 93197991 - KBTBD11 chr8 1973677 2006936 + BMP2K chr4 78776342 78916372 + EXOC7 chr17 76081016 76121576 - SMG5 chr1 156249224 156282825 - SPECC1L chr22 24270817 24417739 + XXYLT1 chr3 195068284 195271159 - NIP7 chr16 69337996 69343106 + MYL5 chr4 673580 682033 + RBPJ chr4 26163455 26435131 + REEP5 chr5 112876385 112922289 - GANAB chr11 62624826 62646726 - DDX6 chr11 118747763 118791164 - METTL26 chr16 634427 636366 - ACAP3 chr1 1292390 1309609 - LRP5 chr11 68312591 68449275 + SUPT5H chr19 39436156 39476670 + MCM2 chr3 127598410 127622436 + HNRNPK chr9 83968083 83980616 - FLNA chrX 154348524 154374638 - SRRM2 chr16 2752626 2772538 + POMGNT1 chr1 46188682 46220305 - PLXNA1 chr3 126988594 127037392 + HDGFL3 chr15 83112738 83207823 - YWHAQ chr2 9583967 9630997 - LMAN2 chr5 177331567 177351668 - HECA chr6 139135080 139180802 + SEC24C chr10 73744372 73772161 + EXTL3 chr8 28600469 28755599 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-1286 chr22 20249145 20249165 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC067930.1 chr8 143579636 143580670 + AD000090.1 chr19 35557956 35581954 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.