exRNAdisease

Entry Detail

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General Information

Database ID: exR0428639 RNA Name: ABI2 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 203328239 End Site(bp): 203447728 External Links: ENSG00000138443

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand C15orf39 chr15 75195643 75212169 + KLC1 chr14 103561896 103714249 + PGAM1 chr10 97426191 97433444 + ESPL1 chr12 53268299 53293638 + COX5B chr2 97646062 97648383 + MYH9 chr22 36281277 36388067 - YWHAQ chr2 9583967 9630997 - HLA-DQA1 chr6 32628179 32647062 + MAN1B1 chr9 137086985 137109183 + PUDP chrX 6667865 7148190 - PEX19 chr1 160276812 160286348 - PKM chr15 72199029 72231822 - TRAF7 chr16 2155698 2178129 + DICER1 chr14 95086228 95158010 - LAMTOR4 chr7 100148907 100155944 + ATN1 chr12 6924463 6942321 + LMNB1 chr5 126776623 126837020 + AL139300.1 chr14 103562962 103685924 + SLC15A4 chr12 128793194 128823958 - CCT2 chr12 69585426 69601570 + NPLOC4 chr17 81556887 81648465 - MT-CO3 chrMT 9207 9990 + SLC9A3R1 chr17 74748628 74769353 + API5 chr11 43311963 43344529 + HSDL2 chr9 112380080 112472405 + BOLA2-SMG1P6 chr16 29443230 29454651 - TXNDC5 chr6 7881517 7910788 - C9orf40 chr9 74946583 74952912 - RPL22L1 chr3 170864875 170870208 - HYOU1 chr11 119044188 119057227 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-218-5p chr5 168768211 168768231 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC079354.2 chr2 202178660 202179391 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.