exRNAdisease

Entry Detail

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General Information

Database ID: exR0428643 RNA Name: ABL1 RNA Type: mRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 130713016 End Site(bp): 130887675 External Links: ENSG00000097007

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CXCL12 chr10 44370165 44386493 - ASXL2 chr2 25733753 25878487 - TMEM115 chr3 50354750 50359521 - STK11 chr19 1177558 1228431 + TMEM214 chr2 27032910 27041694 + NOP53 chr19 47745546 47757058 + TSC2 chr16 2047967 2089491 + CHTOP chr1 153633982 153646306 + ZMYM3 chrX 71239624 71255146 - NUTF2 chr16 67846923 67872567 + DBNDD2 chr20 45406057 45410610 + PCGF2 chr17 38733898 38749817 - TM9SF3 chr10 96518110 96587452 - CHD4 chr12 6570082 6614524 - AP000350.4 chr22 23862188 23895223 + PLCG1 chr20 41136960 41196801 + ACTB chr7 5527148 5563784 - ATE1 chr10 121740421 121928801 - TSPAN6 chrX 100627108 100639991 - TRAF2 chr9 136881912 136926607 + HMGN4 chr6 26538366 26546933 + ETS2 chr21 38805183 38824955 + LAMP5 chr20 9514358 9530524 + MOV10 chr1 112673141 112700746 + GLUL chr1 182381704 182392206 - TPM4 chr19 16067021 16103002 + SIGIRR chr11 405716 417455 - HNRNPD chr4 82352498 82374503 - CORO7 chr16 4354542 4425705 - ZNF319 chr16 57994668 58000453 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-432-5p chr14 100884496 100884518 + hsa-miR-520a-5p chr19 53690895 53690915 + hsa-miR-650 chr22 22822791 22822811 + hsa-miR-330-5p chr19 45639049 45639070 - hsa-miR-760 chr1 93846880 93846899 + hsa-miR-1270 chr19 20399320 20399342 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007993.3 chr17 43914433 43923001 - AC069281.2 chr7 100572232 100578700 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.