exRNAdisease

Entry Detail

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General Information

Database ID: exR0428674 RNA Name: AC008878.3 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 7382834 End Site(bp): 7470241 External Links: ENSG00000268861

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TRABD chr22 50185915 50199598 + RRP1B chr21 43659560 43696079 + MCM2 chr3 127598410 127622436 + PHTF1 chr1 113696831 113759489 - CNOT3 chr19 54137749 54155681 + TBX3 chr12 114670255 114684175 - CKAP4 chr12 106237881 106304279 - MEX3D chr19 1554669 1568058 - MSI1 chr12 120341330 120369164 - FAAP100 chr17 81539885 81553961 - ABHD15 chr17 29560547 29567037 - NFIC chr19 3314403 3469217 + RAPGEF4 chr2 172735274 173052893 + ARHGEF18 chr19 7395113 7472484 + ZNF362 chr1 33256492 33300719 + ENAH chr1 225486835 225653142 - RBM47 chr4 40423267 40630875 - SKI chr1 2228319 2310213 + ACTG1 chr17 81509971 81523847 - CTSF chr11 66563464 66568841 - SF1 chr11 64764606 64778786 - NPDC1 chr9 137039463 137046179 - ECHDC3 chr10 11742366 11764070 + ANXA7 chr10 73375101 73414076 - FERMT3 chr11 64206678 64223886 + EPHB3 chr3 184561785 184582408 + REPIN1 chr7 150368189 150374044 + KDM5C chrX 53191321 53225422 - PDLIM1 chr10 95237572 95291012 - HIPK1 chr1 113929324 113977869 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC073111.3 chr7 150379329 150410597 + AL355075.4 chr14 20343048 20343685 - AL359924.1 chr1 237862175 237928321 + AL513327.1 chr1 33307348 33349245 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.