exRNAdisease

Entry Detail

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General Information

Database ID: exR0428686 RNA Name: AC013394.1 RNA Type: mRNA Chromosome: chr15 Starnd: + Coordinate: Start Site(bp): 92883413 End Site(bp): 92949230 External Links: ENSG00000279765

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CHCHD1 chr10 73782047 73783652 + CHD2 chr15 92900189 93027996 + CSTF2T chr10 51695486 51699595 - ERLIN2 chr8 37736601 37758422 + EXOC5 chr14 57200507 57268905 - FADS2 chr11 61792980 61867354 + FAM120B chr6 170290703 170407065 + FASTKD1 chr2 169528508 169573875 - HNRNPR chr1 23303771 23344336 - ITM2C chr2 230864639 230879248 + LSR chr19 35248330 35267964 + MBOAT2 chr2 8852690 9003709 - MDK chr11 46380756 46383837 + MON2 chr12 62466817 62600476 + MT-CO3 chrMT 9207 9990 + NAPRT chr8 143574785 143578649 - NCL chr2 231453531 231483641 - PCNT chr21 46324141 46445769 + PSAT1 chr9 78297125 78330093 + RPL4 chr15 66498015 66524532 - RPRD1A chr18 35984387 36067576 - SEC24D chr4 118722823 118838683 - SH3PXD2B chr5 172325000 172454525 - SLK chr10 103967140 104029233 + SRSF1 chr17 58000919 58007346 - TNRC6C chr17 77959240 78108835 + TUBB chr6 30720352 30725426 + ZPR1 chr11 116773799 116788039 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand GAS5 chr1 173858559 173868882 - LINC01578 chr15 92819540 92899701 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.