exRNAdisease

Entry Detail

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General Information

Database ID: exR0428697 RNA Name: AC026464.4 RNA Type: mRNA Chromosome: chr16 Starnd: + Coordinate: Start Site(bp): 69299682 End Site(bp): 69322700 External Links: ENSG00000260914

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand LCK chr1 32251239 32286165 + CD99 chrX 2691187 2741309 + CPE chr4 165361194 165498547 + TWSG1 chr18 9334767 9402420 + UBE2V1 chr20 50081124 50115959 - HLA-F chr6 29722775 29738528 + STK11 chr19 1177558 1228431 + RPL15 chr3 23916545 23924374 + ALKBH4 chr7 102456238 102464863 - TRRAP chr7 98877933 99050831 + PLOD1 chr1 11934205 11975538 + HIKESHI chr11 86302211 86345943 + GOSR1 chr17 30477362 30527592 + EIF4A1 chr17 7572706 7579006 + EGLN1 chr1 231363751 231422287 - RPS4X chrX 72255679 72277248 - TMEM189-UBE2V1 chr20 50081124 50153637 - FIBP chr11 65883741 65888539 - CNNM3 chr2 96816245 96835382 + PSEN2 chr1 226870184 226896105 + HIF1A chr14 61695513 61748259 + PABPC1 chr8 100685816 100722809 - ACOT7 chr1 6264269 6394391 - RPS19 chr19 41860255 41872925 + DEAF1 chr11 644233 706715 - NUDT4 chr12 93377883 93408146 + LSM4 chr19 18306230 18323274 - SLC25A6 chrX 1386152 1392113 - MT-ND2 chrMT 4470 5511 + HLA-DQA1 chr6 32628179 32647062 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - ADAMTSL4-AS1 chr1 150560202 150574552 - AC020915.1 chr19 58278966 58315197 + AL355075.4 chr14 20343048 20343685 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.