exRNAdisease

Entry Detail

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General Information

Database ID: exR0428703 RNA Name: AC068580.4 RNA Type: mRNA Chromosome: chr11 Starnd: - Coordinate: Start Site(bp): 1734821 End Site(bp): 1763954 External Links: ENSG00000250644

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MRPL37 chr1 54184041 54225464 + SAFB chr19 5623035 5668478 + MED14 chrX 40648305 40735858 - UBP1 chr3 33388336 33441371 - C1GALT1 chr7 7156934 7248616 + WBP1 chr2 74458400 74460891 + CTSD chr11 1752755 1764573 - EEF2 chr19 3976056 3985463 - NBPF3 chr1 21440128 21485005 + NFU1 chr2 69395750 69437628 - UBE2E2 chr3 23203020 23591794 + LRRC14 chr8 144517992 144525172 + BRAF chr7 140719327 140924928 - COX5B chr2 97646062 97648383 + RDH11 chr14 67676800 67695793 - SELENBP1 chr1 151364304 151372707 - IFITM10 chr11 1732406 1750595 - EIF3CL chr16 28379579 28403879 - DCTN1 chr2 74361154 74392087 - ISOC2 chr19 55452985 55462343 - MAST2 chr1 45786987 46036122 + FPGS chr9 127794597 127814327 + PFKFB4 chr3 48517684 48562015 - SURF6 chr9 133328776 133336188 - FLAD1 chr1 154983338 154993111 + DUSP5 chr10 110497907 110511533 + MTRNR2L8 chr11 10507894 10509186 - RCN1 chr11 32090904 32105755 + MAPK8IP3 chr16 1706183 1770317 + ZNF276 chr16 89720400 89740925 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC018521.1 chr17 47945424 47981736 + LINC00963 chr9 129476946 129513687 + MALAT1 chr11 65497688 65506516 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.