exRNAdisease

Entry Detail

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General Information

Database ID: exR0428722 RNA Name: AC104452.1 RNA Type: mRNA Chromosome: chr3 Starnd: - Coordinate: Start Site(bp): 49416777 End Site(bp): 49429314 External Links: ENSG00000283189

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MTRNR2L12 chr3 96617188 96618236 - ANKZF1 chr2 219229783 219236679 + DBNDD1 chr16 90004871 90020128 - HLA-DRA chr6 32439878 32445046 + DYNLL2 chr17 58083419 58095542 + ZNF429 chr19 21496682 21556270 + AKAP12 chr6 151239967 151358559 + CISD2 chr4 102868974 102892807 + MSANTD3-TMEFF1 chr9 100442271 100577636 + ACTB chr7 5527148 5563784 - DGCR2 chr22 19036282 19122454 - GULP1 chr2 188291669 188595931 + CCT2 chr12 69585426 69601570 + AMT chr3 49416778 49422685 - GLA chrX 101393273 101408012 - RPS4X chrX 72255679 72277248 - ATRN chr20 3471018 3651118 + NICN1 chr3 49422946 49429326 - STX7 chr6 132445867 132513198 - DDOST chr1 20651767 20661544 - EIF3E chr8 108201216 108435333 - TMEFF1 chr9 100473149 100577636 + UBB chr17 16380798 16382745 + DAZAP1 chr19 1407569 1435687 + RPS5 chr19 58386400 58394806 + ALDOA chr16 30064164 30070457 + WLS chr1 68098473 68233120 - TBL1XR1 chr3 177019340 177228000 - BRWD1 chr21 39184176 39321559 - CDK4 chr12 57747727 57756013 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand PINK1-AS chr1 20642657 20652193 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.