exRNAdisease

Entry Detail

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General Information

Database ID: exR0428739 RNA Name: ACAA1 RNA Type: mRNA Chromosome: chr3 Starnd: - Coordinate: Start Site(bp): 38103129 End Site(bp): 38137242 External Links: ENSG00000060971

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NDUFS8 chr11 68030617 68036644 + SYNGR2 chr17 78168558 78173527 + ATXN7L2 chr1 109483479 109492804 + EIF3B chr7 2354086 2380745 + MARCKSL1 chr1 32333839 32336233 - COTL1 chr16 84565596 84618078 - ZNF331 chr19 53519527 53580269 + RPS3 chr11 75399515 75422280 + ICMT chr1 6221193 6235972 - ZFHX3 chr16 72782885 73891871 - TPP1 chr11 6612768 6619448 - RPL37A chr2 216498825 216579180 + TIMP2 chr17 78852977 78925387 - ST6GAL1 chr3 186930502 187078553 + DCTN5 chr16 23641466 23677472 + PTOV1 chr19 49850735 49860744 + KCTD13 chr16 29905012 29926236 - TRAP1 chr16 3651639 3717553 - CEP295NL chr17 78870910 78903217 - RPL11 chr1 23691742 23696835 + LMNB1 chr5 126776623 126837020 + MRPS27 chr5 72219409 72320646 - DDX3Y chrY 12904108 12920478 + NPNT chr4 105894775 106004027 + MTRNR2L12 chr3 96617188 96618236 - LIN28A chr1 26410817 26429728 + MPRIP chr17 17042545 17217679 + HDAC1 chr1 32292083 32333635 + ZBTB40 chr1 22428838 22531157 + RPS4X chrX 72255679 72277248 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-4449 chr4 52712720 52712741 + circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.