exRNAdisease

Entry Detail

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General Information

Database ID: exR0428741 RNA Name: ACACA RNA Type: mRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 37084992 End Site(bp): 37406836 External Links: ENSG00000278540

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand XPNPEP3 chr22 40857077 40932815 + SORT1 chr1 109309568 109397918 - LSM2 chr6 31797396 31806966 - RB1CC1 chr8 52622458 52745843 - ATXN1L chr16 71845976 71885268 + EIF3F chr11 7970251 8001862 + RPL10A chr6 35468401 35470785 + RAB40B chr17 82654973 82698698 - GANAB chr11 62624826 62646726 - NPC2 chr14 74476192 74494177 - PMAIP1 chr18 59899948 59904306 + TCF19 chr6 31158547 31167159 + ATP2A2 chr12 110280756 110351093 + METTL9 chr16 21597218 21657473 + KMT2D chr12 49018975 49059774 - GAPDH chr12 6534512 6538374 + TLE3 chr15 70047790 70098176 - SEPHS1 chr10 13317428 13348298 - AC079447.1 chr2 99141485 99322741 + FBXW11 chr5 171861549 172006873 - FBRS chr16 30658431 30670810 + FAM126A chr7 22889371 23014130 - IQGAP1 chr15 90388242 90502239 + CACHD1 chr1 64470129 64693058 + PDE8A chr15 84980440 85139145 + DVL1 chr1 1335276 1349418 - SIMC1 chr5 176238367 176345991 + MRPL57 chr13 21176658 21179084 + MTRNR2L8 chr11 10507894 10509186 - DDX6 chr11 118747763 118791164 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-541-3p chr14 101064548 101064569 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008514.1 chr5 170747047 170788650 - AD000090.1 chr19 35557956 35581954 + AC079601.2 chr12 42459366 42466128 + AC138761.1 chr17 22266395 22288301 + AP001496.2 chr18 5232876 5238526 - MIR663AHG chr20 26167817 26251546 - MMP25-AS1 chr16 3037400 3059370 - RMRP chr9 35657751 35658018 - RMST chr12 97430884 97598415 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.