exRNAdisease

Entry Detail

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General Information

Database ID: exR0428772 RNA Name: ACKR3 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 236567787 End Site(bp): 236582354 External Links: ENSG00000144476

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CBSL chr21 6444869 6468040 - EIF3C chr16 28688558 28735730 + TOP2B chr3 25597905 25664907 - HNRNPH2 chrX 101408222 101414133 + EXOC8 chr1 231332753 231337852 - TMEM106B chr7 12211270 12243367 + AHCY chr20 34280268 34311802 - PKM chr15 72199029 72231822 - HMGB2 chr4 173331376 173334432 - SPTAN1 chr9 128552558 128633662 + ADK chr10 74151202 74709963 + AKAP1 chr17 57085092 57121346 + LIN28A chr1 26410817 26429728 + RPL13A chr19 49487554 49492308 + CTNND1 chr11 57753243 57819546 + ZNF318 chr6 43307134 43369647 - CCT4 chr2 61868085 61888671 - PRICKLE3 chrX 49174802 49186528 - WDR83OS chr19 12668073 12669415 - ARNT chr1 150809713 150876708 - EZR chr6 158765741 158819368 - CBS chr21 43053191 43076943 - HEY2 chr6 125747664 125761269 + PHC2 chr1 33323623 33431052 - RIBC2 chr22 45413693 45432509 + HLA-DRB5 chr6 32517353 32530287 - NAP1L1 chr12 76036585 76084958 - HNRNPA1 chr12 54280193 54287088 + EIF4A3 chr17 80134369 80147151 - CLSTN1 chr1 9728926 9823984 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-455-3p chr9 114209487 114209507 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007743.1 chr2 56173534 56185870 - AC132217.1 chr11 2129121 2129964 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.