exRNAdisease

Entry Detail

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General Information

Database ID: exR0428776 RNA Name: ACO1 RNA Type: mRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 32384603 End Site(bp): 32454769 External Links: ENSG00000122729

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand UBA52 chr19 18571730 18577550 + SLC25A6 chrX 1386152 1392113 - PCGF3 chr4 705748 770640 + INSR chr19 7112255 7294414 - EEF2 chr19 3976056 3985463 - UNG chr12 109097574 109110992 + STRN4 chr19 46719511 46746994 - MIF chr22 23894383 23895227 + CRMP1 chr4 5748084 5893086 - TOP2A chr17 40388525 40417896 - RAB3D chr19 11322068 11346270 - RPL17 chr18 49488453 49492523 - RPL23 chr17 38847860 38853764 - TMEM250 chr9 136114581 136118875 - IGFBP5 chr2 216672105 216695549 - XRCC5 chr2 216107464 216206303 + RPL27 chr17 42998273 43002959 + ZNF681 chr19 23739195 23758891 - RLF chr1 40161387 40240921 + IMMT chr2 86143932 86195770 - ECD chr10 73130155 73169055 - PTPN11 chr12 112418351 112509913 + TPT1 chr13 45333471 45341370 - DAD1 chr14 22564907 22589224 - AKAP1 chr17 57085092 57121346 + CDCA7L chr7 21900899 21945903 - BID chr22 17734138 17774770 - WDR27 chr6 169457212 169702067 - CCT7 chr2 73233420 73253021 + CD274 chr9 5450503 5470566 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand OIP5-AS1 chr15 41283990 41309737 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.