exRNAdisease

Entry Detail

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General Information

Database ID: exR0428785 RNA Name: ACOT9 RNA Type: mRNA Chromosome: chrX Starnd: - Coordinate: Start Site(bp): 23701055 End Site(bp): 23766475 External Links: ENSG00000123130

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CALM2 chr2 47160083 47176921 - NKX1-2 chr10 124445243 124450035 - PKP3 chr11 392614 404908 + GDI2 chr10 5765223 5842132 - RPLP1 chr15 69452814 69456205 + TTLL3 chr3 9808086 9855138 + KPNA5 chr6 116681187 116741867 + PKN2 chr1 88684222 88836255 + PLEKHB2 chr2 131104847 131353709 + AIP chr11 67483026 67491103 + MT-CO2 chrMT 7586 8269 + NUP155 chr5 37288137 37371106 - PIEZO1 chr16 88715338 88785220 - N4BP2L2 chr13 32432417 32538885 - OCLN chr5 69492292 69558104 + CEP55 chr10 93496612 93529092 + HLA-C chr6 31268749 31272130 - PNPO chr17 47941506 47949308 + MYDGF chr19 4641374 4670362 - SSBP1 chr7 141738334 141787922 + NECAP2 chr1 16440721 16460078 + RPS16 chr19 39433137 39435949 - HMGCS1 chr5 43287470 43313512 - DICER1 chr14 95086228 95158010 - ANKRD46 chr8 100509752 100559784 - PCBP1 chr2 70087477 70089203 + PHTF2 chr7 77798792 77957503 + RGS1 chr1 192575763 192580024 + ADNP chr20 50888916 50931437 - CD74 chr5 150400041 150412929 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand JPX chrX 73944182 74070408 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.