exRNAdisease

Entry Detail

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General Information

Database ID: exR0428799 RNA Name: ACSL1 RNA Type: mRNA Chromosome: chr4 Starnd: - Coordinate: Start Site(bp): 184755595 End Site(bp): 184826818 External Links: ENSG00000151726

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACOT7 chr1 6264269 6394391 - ACP6 chr1 147629652 147670524 - ALMS1 chr2 73385758 73625166 + APOBEC3G chr22 39077067 39087743 + BCAT2 chr19 48795062 48811029 - CCL22 chr16 57358783 57366189 + CHST12 chr7 2403588 2448484 + CPNE1 chr20 35626031 35664956 - DDB1 chr11 61299451 61342596 - DPYSL2 chr8 26514031 26658178 + ENOSF1 chr18 670318 712662 - FADS2 chr11 61792980 61867354 + FBL chr19 39834458 39846379 - HNRNPH1 chr5 179614178 179634784 - IMP3 chr15 75639085 75648706 - LPXN chr11 58526871 58578220 - NAA16 chr13 41311267 41377030 + POLL chr10 101578882 101588270 - PTDSS2 chr11 448268 491399 + TMEM170A chr16 75443054 75465497 - TWNK chr10 100987367 100994403 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-34a-5p chr1 9151735 9151756 - hsa-miR-205-5p chr1 209432166 209432187 + hsa-miR-34c-5p chr11 111513451 111513473 + hsa-miR-337-3p chr14 100874553 100874574 + hsa-miR-449a chr5 55170586 55170607 - hsa-miR-449b-5p chr5 55170706 55170727 - circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.