exRNAdisease

Entry Detail

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General Information

Database ID: exR0428811 RNA Name: ACSS3 RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 80936414 End Site(bp): 81261210 External Links: ENSG00000111058

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TRAM1L1 chr4 117083554 117085576 - NMNAT2 chr1 183248237 183418380 - EPB41L2 chr6 130839347 131063322 - CNST chr1 246566444 246668595 + TJP1 chr15 29699367 29968865 - UBL7 chr15 74445977 74461182 - SENP3-EIF4A1 chr17 7563287 7578715 + UBE2E1 chr3 23805955 23891640 + MIDN chr19 1248553 1259140 + TUBB chr6 30720352 30725426 + KXD1 chr19 18557762 18569387 + U2SURP chr3 142964497 143060725 + TPI1 chr12 6867119 6870948 + UBE2D2 chr5 139526431 139628434 + SCAPER chr15 76347904 76905444 - PTGES3 chr12 56663341 56688408 - DEK chr6 18223860 18264548 - OPRD1 chr1 28812142 28871267 + POLR1D chr13 27620742 27744237 + RPS23 chr5 82273320 82278396 - EIF4A1 chr17 7572706 7579006 + RHEB chr7 151466012 151520120 - RPS6KC1 chr1 213051233 213274774 + ME2 chr18 50879080 50954257 + ARF4 chr3 57571363 57598220 - ENO1 chr1 8861000 8879190 - SWT1 chr1 185157080 185291781 + CRABP2 chr1 156699606 156705816 - NONO chrX 71283192 71301168 + HMGN4 chr6 26538366 26546933 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - NIFK-AS1 chr2 121649320 121728563 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.