exRNAdisease

Entry Detail

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General Information

Database ID: exR0428812 RNA Name: ACTA2 RNA Type: mRNA Chromosome: chr10 Starnd: - Coordinate: Start Site(bp): 88935074 End Site(bp): 88991339 External Links: ENSG00000107796

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZNF516 chr18 76357682 76495242 - HNRNPDL chr4 82422564 82430408 - RPS16 chr19 39433137 39435949 - HLA-B chr6 31269491 31357188 - ATP5F1B chr12 56638175 56645984 - TMSB4X chrX 12975110 12977227 + HLA-A chr6 29941260 29945884 + POTEF chr2 130073535 130129222 - GCN1 chr12 120127202 120194715 - HNRNPH3 chr10 68331174 68343191 + TRAP1 chr16 3651639 3717553 - ATP5PB chr1 111448864 111462773 + PWWP2B chr10 132397168 132417859 + PHF23 chr17 7235029 7239722 - HLA-DMA chr6 32948613 32969094 - RPS8 chr1 44775251 44778779 + PEX2 chr8 76980258 77001044 - BAIAP2L1 chr7 98291650 98401090 - CLUH chr17 2689386 2712663 - UQCRC1 chr3 48599002 48610976 - CCT7 chr2 73233420 73253021 + HLA-DQA1 chr6 32628179 32647062 + ACTG1 chr17 81509971 81523847 - CNBP chr3 129169484 129183922 - PTTG1 chr5 160421855 160428739 + ATN1 chr12 6924463 6942321 + DDIT4 chr10 72273924 72276036 + POLN chr4 2071918 2242121 - RAB12 chr18 8609437 8639382 + RARA chr17 40309180 40357643 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC139149.1 chr17 81514047 81527776 + AC013269.1 chr2 130530275 130537182 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.