exRNAdisease

Entry Detail

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General Information

Database ID: exR0428813 RNA Name: ACTB RNA Type: mRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 5527148 End Site(bp): 5563784 External Links: ENSG00000075624

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACTN1 chr14 68874143 68979440 - AIP chr11 67483026 67491103 + ACAT1 chr11 108116695 108147603 + ACIN1 chr14 23058564 23095614 - AC138894.1 chr16 28456371 28492098 - ACTA2 chr10 88935074 88991339 - AAMP chr2 218264123 218270257 - ADPGK chr15 72751369 72785846 - AC068946.2 chr2 219209772 219222738 - AC104452.1 chr3 49416777 49429314 - AC010132.3 chr7 42909273 42932174 - ACTR10 chr14 58200080 58235636 + ADAM8 chr10 133262420 133276868 - ALDOA chr16 30064164 30070457 + AC011448.1 chr19 19516227 19536076 + AC012184.2 chr16 70299194 70372582 + AL109827.1 chr20 35632340 35674544 - ABCF1 chr6 30571393 30597179 + AC124312.1 chr15 24955034 25000276 + AC098850.3 chr17 16690261 16804453 + ACLY chr17 41866917 41930542 - ACTBL2 chr5 57480018 57482811 - AC010463.1 chr19 17267418 17282966 + AKIRIN1 chr1 38991276 39006059 + ABCB7 chrX 75051048 75156732 - AC010422.3 chr19 12643831 12648397 - AC015813.2 chr17 57989038 58007246 - ACTN4 chr19 38647649 38731589 + AD000671.2 chr19 35739252 35745432 - AL136295.4 chr14 24180395 24190416 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-155-5p chr21 25573983 25574006 + hsa-miR-367-3p chr4 112647877 112647898 - hsa-miR-7847-3p chr11 1880105 1880125 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AD000090.1 chr19 35557956 35581954 + AC013269.1 chr2 130530275 130537182 + AC007326.5 chr22 18936411 18947741 + AL139819.1 chr10 100335563 100346390 - HOXC-AS2 chr12 53993810 53996785 - AC087190.3 chr16 9104848 9113181 + LINC01641 chr1 227393554 227431035 + SNHG5 chr6 85650491 85678932 - OIP5-AS1 chr15 41283990 41309737 + AC091564.7 chr11 6610883 6616594 - AC079466.1 chr19 28606688 28615229 + SNHG6 chr8 66921684 66926398 - SNHG22 chr18 49814023 49851059 + AC139149.1 chr17 81514047 81527776 + MIR155HG chr21 25561909 25575168 + AL023653.1 chrX 129794994 129796963 + AC098850.4 chr17 16788057 16816540 + AL356488.2 chr1 109100193 109100619 + AC004943.1 chr16 72805998 72809872 + AC016876.2 chr17 7581964 7584086 - AC079781.5 chr7 97851688 97972985 - GAS5 chr1 173858559 173868882 - AL359924.1 chr1 237862175 237928321 + LINC01896 chr18 78976555 78979074 - AC055811.1 chr17 17167946 17185554 - AC079949.1 chr12 127142029 127146532 - ESRG chr3 54632122 54639857 - LINC00662 chr19 27681072 27794005 - AL022311.1 chr22 37876148 37895563 + TERC chr3 169764520 169765060 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.