exRNAdisease

Entry Detail

---



General Information

Database ID: exR0428814 RNA Name: ACTC1 RNA Type: mRNA Chromosome: chr15 Starnd: - Coordinate: Start Site(bp): 34790230 End Site(bp): 34795549 External Links: ENSG00000159251

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SLC12A6 chr15 34229784 34338060 - PRKDC chr8 47773111 47960178 - POTEI chr2 130459455 130509707 - VAT1 chr17 43014607 43025123 - IL16 chr15 81159575 81314058 + PCNA chr20 5114953 5126626 - FAM185A chr7 102748971 102809225 + RPS17 chr15 82536750 82540459 - EDC3 chr15 74630558 74696292 - TBC1D9B chr5 179862066 179907859 - ZBTB45 chr19 58513530 58538911 - B2M chr15 44711487 44718877 + EID1 chr15 48878134 48880173 + ENO2 chr12 6913745 6923698 + UBQLN4 chr1 156035299 156053798 - ATP1A1 chr1 116372668 116410261 + AP1G1 chr16 71729000 71809201 - SNRPB chr20 2461634 2470853 - RPL26 chr17 8377516 8383213 - G6PD chrX 154531391 154547572 - CAND1 chr12 67269358 67319953 + TPI1 chr12 6867119 6870948 + AC245033.1 chr15 82536788 82573194 - ACTR1A chr10 102461881 102502712 - CASC4 chr15 44288719 44415758 + ACTA1 chr1 229431245 229434098 - SORL1 chr11 121452314 121633763 + JTB chr1 153974269 153977674 - VPS51 chr11 65089324 65111862 + SERF2 chr15 43777087 43802589 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC019205.1 chr6 73263212 73301789 + AC105339.2 chr15 82752884 82757208 + AC139149.1 chr17 81514047 81527776 + AC012379.1 chr15 48783190 48784121 + AC135178.2 chr17 8318088 8318712 - AL359924.1 chr1 237862175 237928321 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.