exRNAdisease

Entry Detail

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General Information

Database ID: exR0428815 RNA Name: ACTG1 RNA Type: mRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 81509971 End Site(bp): 81523847 External Links: ENSG00000184009

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006064.6 chr12 6556886 6607367 - AATF chr17 36948954 37056871 + ALDOA chr16 30064164 30070457 + AK3 chr9 4709556 4742043 - AFF1 chr4 86935002 87141054 + AL603832.3 chr1 112702614 112711433 - ALAS1 chr3 52198086 52214327 + AC116366.3 chr5 132410832 132646079 + ADGRL1 chr19 14147743 14206187 - ABLIM1 chr10 114431113 114768061 - AK4 chr1 65147549 65232145 + AL136295.1 chr14 24189157 24213473 - AL365205.1 chr6 41780349 41790141 + AC010323.1 chr19 8308283 8321379 - ACTL6A chr3 179562886 179588407 + AL049629.2 chr11 33698261 33722467 - AC005943.1 chr19 1578339 1605445 - ACTR2 chr2 65227753 65271253 + ACTA1 chr1 229431245 229434098 - ADD1 chr4 2843857 2930076 + AK2 chr1 33007940 33080996 - AKIRIN1 chr1 38991276 39006059 + ACTB chr7 5527148 5563784 - ACAP1 chr17 7336529 7351477 + AKAP12 chr6 151239967 151358559 + AL590764.2 chrX 71103987 71111575 - ACTG2 chr2 73892314 73919865 + ACTC1 chr15 34790230 34795549 - ADGRL3 chr4 61201258 62078335 + ABHD16A chr6 31686955 31703356 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-let-7d-5p chr9 94178841 94178862 + hsa-let-7f-5p chrX 53557246 53557267 - hsa-miR-155-5p chr21 25573983 25574006 + hsa-miR-636 chr17 76736466 76736488 - hsa-miR-3648 chr21 8987026 8987046 + hsa-miR-3654 chr7 133034860 133034878 - hsa-miR-6125 chr12 62260418 62260437 + hsa-miR-7703 chr14 24143489 24143511 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC091729.3 chr7 1160374 1165607 + HLA-F-AS1 chr6 29726601 29749049 - EPB41L4A-AS1 chr5 112160526 112164818 + MALAT1 chr11 65497688 65506516 + AC245014.3 chr1 145281116 145281462 + AC020928.1 chr19 36773112 36777078 + AC055811.1 chr17 17167946 17185554 - ANKRD44-IT1 chr2 197250858 197302519 - UBR5-AS1 chr8 102239394 102253750 + SNHG14 chr15 24978583 25420336 + SNHG8 chr4 118278709 118285316 + AL136985.3 chr1 58715609 58771295 + FOXD3-AS1 chr1 63320884 63324441 - AC096649.2 chr2 175167904 175168522 + ZFAS1 chr20 49278178 49299600 + AC087239.1 chr12 25385670 25386241 - AC135178.2 chr17 8318088 8318712 - FAM111A-DT chr11 59130133 59143015 - AC012379.1 chr15 48783190 48784121 + SNHG15 chr7 44983023 44986961 - BISPR chr19 17405686 17419324 + AC002091.1 chr17 8967523 8976995 + XIST chrX 73820649 73852723 - AC007996.1 chr18 26542971 26545791 - AL139819.1 chr10 100335563 100346390 - AL645728.1 chr1 1574102 1577075 + AL355075.4 chr14 20343048 20343685 - PSMB8-AS1 chr6 32844078 32846500 + AC079949.1 chr12 127142029 127146532 - AC021078.1 chr5 149494314 149504670 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.