exRNAdisease

Entry Detail

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General Information

Database ID: exR0428816 RNA Name: ACTG2 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 73892314 End Site(bp): 73919865 External Links: ENSG00000163017

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand POTEE chr2 131218067 131265278 + ACTG1 chr17 81509971 81523847 - GADD45A chr1 67685201 67688334 + LSM11 chr5 157743712 157760709 + NGRN chr15 90265659 90278141 + MTRNR2L1 chr17 22523111 22524663 + CNN1 chr19 11538767 11550323 + BOLA1 chr1 149887890 149900798 + NBEAL1 chr2 203014879 203226378 + HNRNPA2B1 chr7 26173057 26201529 - LRPPRC chr2 43886224 43995989 - SNX17 chr2 27370496 27377535 + PPIG chr2 169584344 169641406 + SLC25A3 chr12 98593591 98606379 + SYPL1 chr7 106090503 106112576 - MCM3AP chr21 46235133 46286297 - POTEI chr2 130459455 130509707 - ACTA2 chr10 88935074 88991339 - COMT chr22 19941733 19969975 + RAB10 chr2 26034084 26137454 + ANP32A chr15 68778535 68820897 - ASB3 chr2 53532672 53860160 - PKM chr15 72199029 72231822 - CAMP chr3 48223347 48225491 + POTEJ chr2 130611481 130658091 + SDHA chr5 218241 257082 + HSP90B1 chr12 103930107 103953645 + WNT5B chr12 1529891 1647212 + ACTB chr7 5527148 5563784 - ACTC1 chr15 34790230 34795549 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC013269.1 chr2 130530275 130537182 + AL359924.1 chr1 237862175 237928321 + EIF1B-AS1 chr3 40061110 40309698 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.