exRNAdisease

Entry Detail

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General Information

Database ID: exR0428818 RNA Name: ACTL6A RNA Type: mRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 179562886 End Site(bp): 179588407 External Links: ENSG00000136518

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RNF167 chr17 4940008 4945222 + FIGN chr2 163593396 163736012 - NPTX2 chr7 98617285 98629869 + ASGR1 chr17 7173431 7179564 - SIX4 chr14 60709539 60724351 - RUFY1 chr5 179550554 179610012 + PABPC1 chr8 100685816 100722809 - AC015813.2 chr17 57989038 58007246 - EEF2 chr19 3976056 3985463 - AC084337.2 chr11 6481485 6508978 + PRPF8 chr17 1650629 1684867 - MT-ND1 chrMT 3307 4262 + CALM1 chr14 90396502 90408268 + INTS6 chr13 51354077 51454264 - HSPA5 chr9 125234853 125241343 - RPL38 chr17 74203582 74210655 + TUBB chr6 30720352 30725426 + GATA2 chr3 128479427 128493201 - ALPL chr1 21509397 21578410 + KMT2A chr11 118436490 118526832 + RHOA chr3 49359145 49412998 - GHITM chr10 84139509 84153568 + MT-CO3 chrMT 9207 9990 + RPS16 chr19 39433137 39435949 - NRBP1 chr2 27427790 27442259 + OAZ1 chr19 2269509 2273490 + B3GNT2 chr2 62196115 62224731 + YPEL3 chr16 30092314 30096915 - JAKMIP1 chr4 6026199 6200591 - WDYHV1 chr8 123416726 123470028 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand ARMCX5-GPRASP2 chrX 102599512 102714671 + RMRP chr9 35657751 35658018 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.